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dcc sirnas  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology dcc sirnas
    Dcc Sirnas, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dcc+sirnas/DCC+siRNA/pmc04734837-97-2-16
    Average 90 stars, based on 2 article reviews
    dcc sirnas - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Droplet Countercurrent Chromatography:

    Article Title: Targeting netrin‐1/ DCC interaction in diffuse large B‐cell and mantle cell lymphomas
    Article Snippet: .. Netrin‐1 and DCC siRNAs were designed as a pool of three target‐specific siRNAs of 20–25 nucleotides (Santa Cruz biotechnologies, Inc.). .. Scrambled siRNA that does not trigger degradation of any specific messenger was used as a control (Santa Cruz biotechnologies, Inc.).



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    The effects of silencing of endogenous Netrin‐1 ( NTN ‐1) by NTN ‐1 <t>small</t> <t>interfering</t> <t>RNA</t> (si RNA ) on blood‐brain barrier integrity at 24 hours after subarachnoid hemorrhage ( SAH ). NTN ‐1 si RNA aggravated neurological deficits (A) and increased brain water content (B) and Evans blue ( EB ) extravasation (C) in both hemispheres. n=6 for each group. D, Representative fluorescent micrograph of EB extravasation and quantitative analyses of the intensity of EB fluorescence in the ipsilateral cortex. n=2 for each group. * P <0.05 vs sham, # P <0.05 vs Vehicle, & P <0.05 vs NTN ‐1 and Scr si RNA ; @ P <0.05 vs NTN ‐1. LH indicates left hemisphere; RH , right hemisphere; Scr si RNA , scramble si RNA . Scale bar=25 μm.
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    Image Search Results


    The effects of silencing of endogenous Netrin‐1 ( NTN ‐1) by NTN ‐1 small interfering RNA (si RNA ) on blood‐brain barrier integrity at 24 hours after subarachnoid hemorrhage ( SAH ). NTN ‐1 si RNA aggravated neurological deficits (A) and increased brain water content (B) and Evans blue ( EB ) extravasation (C) in both hemispheres. n=6 for each group. D, Representative fluorescent micrograph of EB extravasation and quantitative analyses of the intensity of EB fluorescence in the ipsilateral cortex. n=2 for each group. * P <0.05 vs sham, # P <0.05 vs Vehicle, & P <0.05 vs NTN ‐1 and Scr si RNA ; @ P <0.05 vs NTN ‐1. LH indicates left hemisphere; RH , right hemisphere; Scr si RNA , scramble si RNA . Scale bar=25 μm.

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: Netrin‐1 Preserves Blood‐Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats

    doi: 10.1161/JAHA.116.005198

    Figure Lengend Snippet: The effects of silencing of endogenous Netrin‐1 ( NTN ‐1) by NTN ‐1 small interfering RNA (si RNA ) on blood‐brain barrier integrity at 24 hours after subarachnoid hemorrhage ( SAH ). NTN ‐1 si RNA aggravated neurological deficits (A) and increased brain water content (B) and Evans blue ( EB ) extravasation (C) in both hemispheres. n=6 for each group. D, Representative fluorescent micrograph of EB extravasation and quantitative analyses of the intensity of EB fluorescence in the ipsilateral cortex. n=2 for each group. * P <0.05 vs sham, # P <0.05 vs Vehicle, & P <0.05 vs NTN ‐1 and Scr si RNA ; @ P <0.05 vs NTN ‐1. LH indicates left hemisphere; RH , right hemisphere; Scr si RNA , scramble si RNA . Scale bar=25 μm.

    Article Snippet: Following the manufacturer's instructions, rat NTN‐1 siRNA (Thermo Fisher Scientific, Waltham, MA), DCC siRNA (OriGene Technologies, Rockville, MD), or negative control scramble siRNA (OriGene Technologies) was dissolved in transfection reagent (OriGene Technologies).

    Techniques: Small Interfering RNA, Fluorescence

    Changes in expressions of downstream signaling pathway of Focal Adhesion Kinase ( FAK )/RhoA after exogenous Netrin‐1 ( NTN ‐1) treatment and NTN ‐1 si RNA pretreatment at 24 hours post–subarachnoid hemorrhage ( SAH ). Exogenous NTN ‐1 significantly further enhanced the FAK phosphorylation (A), which resulted in the suppression of RhoA activity (B). While the endogenous NTN ‐1 was depleted by use of NTN ‐1 si RNA , the p‐ FAK level decreased (A), which augmented the RhoA activation (B). The RhoA activity was negatively related to the levels of endothelial tight junction proteins including ZO ‐1 (C) and Occludin (D) in the ipsilateral hemisphere. Relative densities of each protein have been normalized against the sham group. n=6 for each group. * P <0.05 vs sham, # P <0.05 vs vehicle, and & P <0.05 vs NTN ‐1 and Scr si RNA . Scr si RNA indicates scramble si RNA ; siRNA, small interfering RNA.

    Journal: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

    Article Title: Netrin‐1 Preserves Blood‐Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats

    doi: 10.1161/JAHA.116.005198

    Figure Lengend Snippet: Changes in expressions of downstream signaling pathway of Focal Adhesion Kinase ( FAK )/RhoA after exogenous Netrin‐1 ( NTN ‐1) treatment and NTN ‐1 si RNA pretreatment at 24 hours post–subarachnoid hemorrhage ( SAH ). Exogenous NTN ‐1 significantly further enhanced the FAK phosphorylation (A), which resulted in the suppression of RhoA activity (B). While the endogenous NTN ‐1 was depleted by use of NTN ‐1 si RNA , the p‐ FAK level decreased (A), which augmented the RhoA activation (B). The RhoA activity was negatively related to the levels of endothelial tight junction proteins including ZO ‐1 (C) and Occludin (D) in the ipsilateral hemisphere. Relative densities of each protein have been normalized against the sham group. n=6 for each group. * P <0.05 vs sham, # P <0.05 vs vehicle, and & P <0.05 vs NTN ‐1 and Scr si RNA . Scr si RNA indicates scramble si RNA ; siRNA, small interfering RNA.

    Article Snippet: Following the manufacturer's instructions, rat NTN‐1 siRNA (Thermo Fisher Scientific, Waltham, MA), DCC siRNA (OriGene Technologies, Rockville, MD), or negative control scramble siRNA (OriGene Technologies) was dissolved in transfection reagent (OriGene Technologies).

    Techniques: Phospho-proteomics, Activity Assay, Activation Assay, Small Interfering RNA